Study on anti inflammatory effect of subcutaneous honey bee venom injection and dermal application of cream containing honey bee venom in adjuvant-induced arthritic rats

study on anti inflammatory effect of subcutaneous honey bee venom injection and dermal application of cream containing honey bee venom in adjuvant-induced arthritic rats

honey bee sting is used in some societies as a treatment of inflammation in joint diseases such as arthritis. to investigate the effect of honey bee venom in reducing inflammation, we selected 30 male wister rats which were divided in to 6 groups. except group 1, all remaining groups received 0.5 ml of complete freund’s adjuvant to induce arthritis. after 9 days, all animals that received adjuv...

Chemistry and Pharmacology of Honey-bee Venom

Study on anti inflammatory effect of scorpion (Mesobuthus eupeus) venom in adjuvant-induced arthritis in rats

Rheumatoid arthritis is an autoimmune disease that causes chronic inflammation of the joints as well as other organs in the body. Adjuvant-induced arthritis models in inbred rats serve as relevant models for RA, having many clinical similarities to this disease. Using honey bee venom as a treatment for Rheumatoid arthritis is an ancient therapy in various parts of the world. However scorpion ve...

Effect of honey bee venom on differentiation of cholinergic neurons

Mouse P19 embryonic carcinoma (EC) cells are pluripotent and can differentiate into a population consisting largely of neurons and glia cells using a concentration of 5x10(-7)M of retinoic acid (RA). Thus, P19 EC cells are a good model system to study events occurring during the critical phases of neuronal differentiation, in vitro. Honey bee venom (BV) consists of mellitin, phospholipase A2, a...

Antineoplastic Effects of Honey Bee Venom

Article history: Received: 12 Jul 2011 Accepted: 12 Mar 2011 Available online: 30 Dec 2012 ZJRMS 2013; 15(8): 1-5 Background: Bee venom (BV), like many other complementary medicines, has been used for thousands of years for the treatment of a range of diseases. More recently, BV is also being considered as an effective composition for the treatment of cancer. Cancer is a major worldwide proble...

Cytotoxic and Pro-Apoptotic Effects of Honey Bee Venom and Chrysin on Human Ovarian Cancer Cells

Background: The anti-cancer effects of honey bee venom (BV) and chrysin might open a new window for treatment of chemo-resistant cancers. This study was designed to evaluate cytotoxic and pro-apoptotic effects of BV and chrysin on A2780cp cistplatin- resistant human ovarian cancer cells. Methods: As per the study objectives, A2780cp cells were categorized to 4 groups: 3 experiment groups (treat...